The biting assessments were delivered in the dying hours of the legal fight launched by Charlotte MacInnes, the lead actor in musical comedy The Deb, which Wilson directed, co-produced and starred in.
MacInnes claims she was defamed by the first-time director in a series of social media posts that suggested she is a liar and a sellout who walked back a sexual misconduct complaint to further her career.
The posts claimed the young actor confided to Wilson - and later recanted - that she felt uncomfortable when the film's co-producer Amanda Ghost asked to have a shower and a bath together.
MacInnes denies making or retracting a complaint, insisting she was not uncomfortable when the pair shared a bath in their swimwear after Ms Ghost suffered a medical episode in September 2023.
But she gave false evidence under oath to maintain her constructed narrative, Wilson's barrister Dauid Sibtain SC alleged in the Federal Court on Friday.
One example was her evasiveness when asked about the benefits she received from her connection with Ms Ghost, including a lead role and six-figure record deal, he said.
MacInnes wanted to ensure the producer never thought she made a complaint so she could continue building her career to the "stratospheric heights" she now enjoys, Mr Sibtain contended.
"Ms MacInnes has suffered no harm, let alone serious harm," he said.
But MacInnes had not had any acting roles since she starred in a stage production that had been secured before the social media posts, her barrister Sue Chrysanthou SC argued.
"My client has been unable to eat, unable to sleep, has been distressed ... (she) fears what Rebel Wilson is going to do to her next," she said.
MacInnes, who denied giving false statements when questioned in court, is seeking for damages for harm done to her reputation.
Wilson invented a "complete revision of history" littered with multiple glaring inconsistencies, Ms Chrysanthou said.
She noted the Bridesmaids star testified she told a local producer about the alleged complaint on the day it was made to her but the producer said she had not been told MacInnes felt uncomfortable until a week later.
"She is a fantastical liar who has made up terrible, terrible allegations about multiple people and her own witnesses have discredited her," the barrister said.
"We say Ms Wilson cannot be believed on anything she has said."
Wilson lied to Ms Ghost about receiving a complaint to create division between the producer and MacInnes, whom she sought to paint as a troublemaker, Ms Chrysanthou said.
A text from Wilson that accused the young actor of leaking information to the film's writer showed she was set on undermining MacInnes' relationships, she argued.
But it was slammed as a "very weak motive" by Mr Sibtain, who questioned why Wilson would want to drive a wedge between the star of her film and a producer.
"It's clear Ms Wilson had no motive to lie about something as inherently disruptive to the harmony of the film as the making of a false complaint would be," he shot back.
The fabrication would have been quickly resolved by a discussion between MacInnes and Ms Ghost - who lived together at the time - but it had not been because it was the truth, Mr Sibtain said.
Despite her lapses in memory, he said Wilson had been a truthful witness who had rejected suggestions she was lying.
After two weeks of colourful submissions punctuated with Hollywood name drops and multiple side plots, Justice Elizabeth Raper reserved her decision.