Easter for Christians commemorates Christ's triumph over death with his resurrection following his crucifixion. Lighting the candle before he entered the basilica, the pope intoned: "The light of Christ who rises in glory."
Candle bearers stopped to light candles of the congregants as they walked down the central aisle, spreading flickers of light through the dark basilica before the lights went up as the Pope arrived at the baroque main altar, followed by cardinals dressed in white.
In his Saturday night homily, Leo called sin "a heavy barrier that closes us off and separates us from God, seeking to kill his words of hope within us", and likened it to the stone that had covered Jesus' tomb - but which was found overturned, revealing Jesus' resurrection.
Leo said there are stones representing sins to be overturned today, some "so heavy and so closely guarded that they seem to be immovable".
"Some weigh heavily on the human heart, such as mistrust, fear, selfishness and resentment; others stemming from these inner struggles, sever the bonds between us through war, injustice and the isolation of peoples and nations.
"Let us not allow ourselves to be paralysed by them!" the Pope said, calling on the faithful to make a commitment "so that the Easter gifts of harmony and peace may grow and flourish everywhere and always throughout the world".
With the US-Israeli war on Iran in its second month and Russia's ongoing campaign in Ukraine, Leo has repeatedly called for a halt in hostilities.
On Palm Sunday, he said God doesn't listen to the prayers of those who make war or cite God to justify their violence.
As is tradition, Leo baptised 10 adults from all over the world during the mass.
During Leo's first Holy Week, which is notoriously demanding, the pontiff carried the cross for the entire 14 stations during the Way of the Cross on Good Friday, the first time a Pope has done so for decades.
On Holy Thursday, he washed the feet of 12 priests in the traditional Holy Thursday ritual, restoring a tradition his predecessor Pope Francis had broken by including laypeople and non-Christians.
On Sunday morning, Leo will celebrate an open-air mass in St Peter's Square before delivering his Easter message and offer the traditional "Urbi et Orbi" message "to the city (of Rome) and the world", which acts as a summary of the world's woes.
