Police say multiple shots were fired at a house and car on Carnelian Street at Leppington about 9.45pm on Tuesday.
Two men and a woman were inside the house at the time but were uninjured.
Police believe the shooting was targeted and have been told a white van was spotted in the vicinity.
The latest incident comes less than six months after a 28-year-old man was shot three times in the leg on the same street.
State Crime Commander Detective Chief Superintendent Darren Bennett says it had all the hallmarks of the gang violence that has plagued Sydney's west and southwest for 18 months.
"It's another organised crime intimidation style ... with bullets fired into a house and a car," he told the Nine Network.
"It's a typical hallmark of this kind of crime that we're experiencing at the moment.
"Thankfully no one was hurt," he said.
Police are under pressure to curb violence believed to stem from organised crime and the drug trade, following a spate of shootings and 13 deaths over the last 18 months.
Police Commissioner Karen Webb has given a clear mandate to officers that there would be "no tolerance for this type of offending", Det Supt Bennett told ABC TV.
"We're well aware of the community's concern ... we're doing everything we can to alleviate it," he said.
Taskforce Erebus was announced on Monday to target organised crime and has arrested seven members and associates of bikie gangs including Comancheros, Finks and Rebels.
Police have also been given new powers in the form of Drug Supply Prohibition Orders that allow them to apply to a court for an order against anyone who has been convicted of a serious drug offence in the past decade.
People under a DSPO can be searched anywhere at any time by police without the need to apply for a warrant, similarly to Serious Crime Prevention Orders and Firearm Prohibition Orders that police have had for several years.
The orders will be placed on people strongly suspected of being actively involved in the drug trade, NSW Police Assistant Commissioner Mick Fitzgerald said on Tuesday.
"This is not just for young people who have had one conviction," he said.
"These are people who are convicted of supplying prohibited drugs (and) are actively involved in their community supplying drugs."Â
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