Ms Giuffre, 41, who took her own life in 2025 at her farm in Western Australia, alleged that she was forced to have sex on multiple occasions with former Duke of York Andrew Mountbatten-Windsor after Epstein trafficked her.
More than a dozen researchers and practitioners from some of Australia's most influential universities and domestic violence organisations have written a letter to West Australian Coroner Ros Fogliani.
"(Ms) Giuffre spent much of her adult life in courageous pursuit of accountability for the abuse she suffered, taking significant personal risk to expose a network of exploitation and in doing so helping to protect other women," the letter published on Thursday said.
"It would be a profound injustice if the question of whether systems failed her in her final months were not examined with equivalent rigour."
In May, Ms Giuffre's brothers reportedly called for a public inquest into her death by suicide and a formal review of police actions they believe failed to protect her.
They said Ms Guiffre may have been a victim of domestic violence in the lead up to her death.
The latest call for an inquiry was signed by 16 experts, including University of Melbourne professors Heather Douglas and Cathy Humphreys, University of Western Australia professor Melanie O'Brien, University of Technology Sydney associate professor Jane Wangmann, and WA Centre for Women's Safety and Wellbeing chief executive officer Alison Evans.
"(Ms) Giuffre's death is unusual only in that it is visible," the group said.
"Her public profile means there is an unusually detailed record of her final months – and what that record shows is deeply consistent with what our research tells us about how these deaths occur, and how they are too often overlooked."
Ms Giuffre's death raises broader questions about family violence, coercive control and potential systemic failures, the letter said.
''Women with experiences of intimate partner violence often describe feeling dismissed, blamed for the abuse, or redirected into mental health pathways during contact rather than having the violence recognised by health, policing and legal services," Dr Evans said.
''A victim-survivor's distress and suicidal thoughts and behaviours should not be treated as individual disorders."
Ms Giuffre settled a sexual assault lawsuit against the former prince, although he has always denied the allegations.
She also figured prominently in the downfall of Epstein, who was found dead in his New York jail cell in August 2019 while he awaited trial on sex trafficking charges. His death was ruled a suicide.
His former girlfriend, Ghislaine Maxwell, was convicted in late 2021 on sex trafficking and other charges.
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