About 9.40 am, police were enforcing the closure of the Newell Hwy at Tocumwal, when they stopped and spoke with the 24-year-old male driver of a Victorian registered car.
While speaking him, officers noticed that he and his 28-year-old passenger appeared to be drug-affected.
Police conducted a search of the vehicle and located gamma-hydroxybutyric acid (GHB), steroids, two knives, and items consistent with the supply of prohibited drugs.
During a subsequent search of the men, officers located methylamphetamine, buprenorphine and mobile phones. Police also seized a total of $4065 cash.
The men were arrested and taken to Finley Police Station.
The older man, who is from Tocumwal, was charged with supply prohibited drug, deal with property proceeds of crime, and two counts of possess prohibited drug.
The younger man, who is from South Gladstone in Queensland, was charged with supply prohibited drug and deal with property proceeds of crime.
Both men have been refused bail to appear at Albury Local Court on Thursday.
They will also be given directions under the Public Health Act to self-isolate for 14 days.
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