The UK rockers returned to the stage in 2025, following a seven-year hiatus, to play a limited run of shows across Europe with stops in Madrid, Bologna, London, Copenhagen, and Berlin.
Speaking to Rolling Stone, O'Brien said the band has agreed on a long‑term plan that will see them perform in focused bursts rather than undertaking the kind of exhaustive world tours they once did.
Asked if they are hitting the road again, he said: "It's definitely happening.
"What we're going to do is, every year we're going to do a different continent, and we're going to do 20 shows each year. No more, no less."
O'Brien also confirmed Radiohead will remain inactive throughout 2026, but are aiming to regroup the following year.
"We won't do anything this year, but we'll do something next year," he said.
O'Brien explained the new approach is designed to preserve the band's energy and ensure every performance feels meaningful.
"We want to give absolutely everything each night.
"We do not ever want it to be like we're going through the motions or we're having to run on empty. We've got to be able to do it. And you know what? We're not spring chickens anymore."
Regarding future shows, O'Brien added: "Venues get booked so far in advance. To do another we would have to decide now, and even then it wouldn't happen for 18 months."