Four people died when a van carrying nine people left the road on Chapel Rd in front of another motorist.
All of the survivors have suffered serious injuries, some life-threatening.
Three children are among those with life-threatening injuries.
Governor-General Sam Mostyn has reached out to offer support to the community.
“As Governor-General, and on behalf of all Australians, I am writing to express my sorrow at the terrible accident that occurred south of Cobram in Victoria on Monday evening, where four lives were lost,” she said.
“Moira Shire chair administrator Dr Graeme Emonson has shared with me that this tragedy will be felt across your community — especially as it comes after another fatal accident in 2023. It is a terribly challenging and sad time for the region.
“As is often the case in regional towns, the first responders and others involved in the response may know those affected. I also know from Graeme that this a strong, caring and diverse community and that you will support one another in the days ahead.
“As Australians, we are at our best when we are together, and reaching out to one another with care, kindness and respect.
“At this time, when Australians are also focused on the appalling events that took place on Bondi Beach, I want you to know that I am also thinking of you and your community in your grief.
“Take good care of yourselves and each other at this difficult time.”
Dr Emonson said any road accident causing death or injury was a tragedy, but coming only 10 days before Christmas the loss was even harder to comprehend.
“Our thoughts are with those who died or were injured, their loved ones and everyone in the community who will be impacted by this terrible event,” Dr Emonson said.
“Our thoughts are also with our first responders and Victoria Police, who deal with these tragedies on our roads far too often.
“Our deepest thanks for their service.”
Dr Emonson said it was a busy time on the region’s roads, with agricultural equipment on the move during harvest season and extra visitors for Christmas and school holidays.
“We want everyone who lives and works in Moira Shire, and all our visitors, to leave their homes safely in the morning and arrive home again safely at night,” he said.
“Road safety is everyone’s responsibility. Even one life lost is one too many.”
Victoria Police has not yet released information on the identities of the victims.
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