Bangladesh pace trio Taskin Ahmed, Ebadot Hossain and Hasan Mahmud bowled superbly to have the hosts 4-74 at lunch after Australia captain Pat Cummins won the toss and elected to bat first in Darwin on Thursday.
Weatherald had an opportunity to enhance his chances of staying in the top order in front of a partisan crowd in Darwin, the city of his birth, but was unable to make the most of a start in the opening Test at Marrara Stadium.
It was no surprise when the 31-year-old edged impressive paceman Hasan on the cusp of drinks to bring an end to a scratchy 23 off 37 deliveries.
Opening partner Travis Head (22) followed soon after, chopping on to Hasan when he went around the wicket.
Ebadot had Labuschagne (1) edging to captain Najmul Hossain Shanto with an indecisive poke as his drought without scoring a Test century extended to 37 innings.
Ebadot should have claimed the prize scalp of Steve Smith on two when he was dropped by Tanzid Hasan at third slip.
Bangladesh then lost a second review when Smith was given not out on seven after Ebadot was convinced he'd nicked one.
A horror shot by allrounder Cameron Green (13) on the stroke of lunch went straight to mid-wicket to put Bangladesh on top.
Weatherald was unconvincing early after making an adjustment to his set-up at the crease.
Hasan, 26, found a good length and movement to have Weatherald playing and missing.
Weatherald scored just 201 runs at at average of 22.3 in last summer's Ashes and had a technical issue, with his head positioned outside off stump and a tendency to fall over even further.
He adjusted that so that his head was more aligned above the stumps, but his wickets were also exposed on occasions due to his adjusted stance.
An off-drive for four off Hasan was a moment of promise, followed by a cracking cover drive, but the next ill-advised flash proved his undoing.
Cummins had no hesitation in opting to bat when he won the toss, but the decision suited Bangladesh captain Shanto, who liked the look of the surface.
"I think it is a good opportunity for the bowlers," he said.
"It looks a little green with a bit of moisture, so early on there will be some movement."
That assessment proved correct.
The Test is the first played at the venue since 2004 and just the third in Darwin history after Bangladesh were the first visiting side in 2003.
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