Paramedics were called to a two car crash on Cobram South Road this morning.
Three people were injured in the accident, with one person trapped in each vehicle.
A woman aged in her 20s was treated by paramedics for leg injuries.
The woman was flown by air ambulance helicopter to Royal Melbourne Hospital in a critical condition.
A woman aged in her teens from the same car was treated for back and spinal injuries.
She was taken to Goulburn Valley Hospital in a serious condition.
A man aged in his 20s from the other vehicle was taken to Goulburn Valley Hospital in a stable condition.